Hydrafinil Myristate

Hydrafinil myristate is the myristate ester of 9H-fluoren-9-ol: the fluorenyl secondary alcohol acylated with myristic acid, the fourteen-carbon saturated fatty acid. Esterifying a small polar alcohol with a long saturated chain is a standard lipophilicity manoeuvre, and the change it produces is large. The parent alcohol has a molecular weight of 182 and modest water solubility; adding a C14 acyl chain roughly doubles the mass and moves the compound firmly into lipid-like behaviour.

That is the whole point of the molecule as a research object. It is an ester prodrug scaffold, and the interesting chemistry is the hydrolysis: whether, where and how fast the ester bond is cleaved to release the parent alcohol. Ester prodrugs of benzylic alcohols are not always well behaved, because the same aryl stabilisation that makes the fluorenyl position reactive also opens competing routes.

Technical Specifications

Research Applications & Chemistry

The experimental questions this compound supports are almost entirely about the ester bond. A myristate ester is a substrate for carboxylesterases and lipases rather than a spontaneous hydrolyser, so cleavage in a cell-free buffer and cleavage in a tissue homogenate can differ by orders of magnitude. Establishing which enzyme class is responsible, and confirming that the parent alcohol is actually released rather than the molecule being cleared intact, is the first analytical task rather than an assumption.

Primary fields of laboratory investigation include:

• Ester Hydrolysis Kinetics: Measuring cleavage rate in buffer, plasma and tissue homogenate to establish whether hydrolysis is chemical or enzymatic.

• Esterase Substrate Profiling: Identifying which carboxylesterase or lipase activities act on the C14 ester using selective inhibitors.

• Lipophilicity Studies: Determining partition coefficient and membrane association relative to the unesterified parent.

• Formulation Chemistry: Serving as a model lipophilic ester for lipid-vehicle and emulsion formulation work.

• Analytical Method Development: Chromatographic separation of the intact ester from free fluorenol and from myristic acid, which is the assay any hydrolysis experiment depends on.

Selected Research Literature

No peer-reviewed literature indexed on PubMed describes this specific ester. Presenting citations for the parent alcohol or for unrelated myristate esters would imply an evidence base that does not exist for this compound, so none is offered. The chemistry described above follows from the established behaviour of long-chain fatty acid esters and of the fluorene system.

Analytical Documentation

Purity, identity, and composition vary by manufacturing lot. Kimera Chems does not publish a single fixed purity figure for this item; refer to the batch-specific Certificate of Analysis (COA) issued for the lot received, which reflects third-party analytical testing for that lot. Contact us if a COA for your lot is required.

Storage & Handling

Store at controlled room temperature. Keep tightly closed.

Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.