RGPU-95 (p-Cl-Phenylpiracetam) Research Standard

RGPU-95 (p-Cl-Phenylpiracetam) is a synthetic racetam-class compound characterized by the addition of a chlorine atom to the phenylpiracetam scaffold. This structural modification is a focal point in pharmacological research, specifically investigated for how it alters the compound’s stability, lipophilicity, and pharmacological potency in in vitro models. In laboratory settings, RGPU-95 is utilized as a high-potency tool for mapping signal transmission dynamics within nerve tissue and observing cellular responses to stressors in controlled experimental environments.

Technical Specifications

Mechanism of Action & Research Context

The chemical modification of phenylpiracetam with a para-chlorine substituent is what distinguishes RGPU-95 from its parent scaffold.

• Ring Substitution: Chlorine is an electron-withdrawing substituent, so the para-chlorinated phenyl ring is deactivated toward electrophilic attack relative to the unsubstituted ring. What that means for the compound under experimental conditions is one of the things RGPU-95 is used to measure.

• Signaling Modulation: Research focuses on the compound’s interaction with neurotransmitter pathways, particularly its ability to modulate signal velocity and transduction efficiency between neurons in cultured tissue.

• Cellular Resilience: Because the compound is utilized to study cells under “pressure,” it acts as a valuable reference in experiments measuring how neural tissue maintains viability or signaling integrity when exposed to thermal or metabolic stress.

Research Applications

RGPU-95 is a specialized reference material for cognitive science and neuropharmacology.

Primary fields of in vitro laboratory investigation include:

• GABAergic Signaling: Investigating the modulation of GABA receptor activity in isolated nerve tissue models.

• Bioenergetic Stress Testing: Examining energy utilization in neural cells under low-temperature (cold stress) conditions.

• Permeability Studies: Investigating the kinetics of the compound’s movement across cellular barriers and membrane systems.

• Signal Speed Dynamics: Quantifying changes in signal propagation speed between nerve cells in controlled culture environments.

• Comparative Neuropharmacology: Utilizing the chlorinated scaffold to compare binding and activity profiles against the parent phenylpiracetam molecule.

Storage & Handling Guidelines

Store at controlled room temperature. Keep tightly closed. Liquid formats: do not refrigerate or freeze. Cold storage may cause the solution to cloud or precipitate. If this occurs, return to room temperature and mix until clear.

Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.