Lemairamin (WGX-50 / α7nAChR Agonist)

Lemairamin, also identified in research literature as WGX-50, is a synthetic amide derivative characterized by a dimethoxyphenyl group linked to a phenylpropenamide structure. It is extensively utilized in laboratory research as a selective agonist of the α7 nicotinic acetylcholine receptor (α7nAChR). By acting on this specific receptor, Lemairamin serves as a critical probe for investigating pathways related to neuroinflammation, pain hypersensitivity, and neuroprotective signaling mechanisms in cellular models.

Technical Specifications

Research Applications

Lemairamin is a primary tool for probing the functional role of the α7 nicotinic acetylcholine receptor in various experimental biological contexts.

Primary fields of in vitro laboratory investigation include:

• α7nAChR Signaling: Utilizing the compound to trigger and study receptor activation pathways in neuronal and inflammatory cell lines.

• Neuroinflammation Research: Analyzing the role of α7nAChR modulation in attenuating inflammatory responses in microglial and astrocytic models.

• Pain Hypersensitivity Studies: Probing receptor-mediated pathways involved in the modulation of pain signaling.

• Neuroprotective Research: Investigating the compound’s effect on cellular survival pathways under conditions of stress relevant to neurodegenerative research.

• Competitive Binding Studies: Evaluating interaction profiles and receptor occupancy in the presence of other nicotinic ligands.

Storage & Handling Guidelines

Store at controlled room temperature. Keep tightly closed.

Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.